Follicular B-Cell Lymphoma Embedded in a Pulmonary Chondroid Hamartoma: A Case Report

Background: Here we report a rare case of concomitant pulmonary chondroid hamartoma and follicular non Hodgkin lymphoma in a 65-year-old woman with a history of 4-month nonspecifi c symptoms like fever, sweating and weight loss. Methods: Chest CT scan revealed a 12-mm nodule with relatively regular margins in the right middle lung fi eld, adhering to the chest wall, with no involvement of hilar or mediastinal lymph nodes. The patient underwent thoracoscopy and resection of the lesion. Following histological exam and immunohistochemical staining, the patient was diagnosed as having follicular b-cell lymphoma embedded in a pulmonary chondroid hamartoma. FISH analysis was performed and showed the presence of typical follicular lymphoma chromosomal translocation t (14;18) (q32;q21). Conclusions: Following the fi nal diagnosis, we decided not to refer the patient to chemotherapy and she enter watch and wait regimen with imaging control every 6 months. After 18 months, the chest X-ray and abdominal ultrasound are still negative with no evidence of recurrence. Case Report Follicular B-Cell Lymphoma Embedded in a Pulmonary Chondroid Hamartoma: A Case Report Lara Mannelli1*, Sofi a Kovalchuk1, Benedetta Puccini1, Gemma Benelli1, Catia Dini2, Alberto Bosi1 and Luigi Rigacci1 1Department of Hematology, AOU Careggi General and Academic Hospital, Florence, Italy 2Department of Radiodiagnostic, AOU Careggi, General and Academic Hospital, Florence, Italy Dates: Received: 17 February, 2017; Accepted: 08 March, 2017; Published: 09 March, 2017 *Corresponding author: Lara Mannelli, Department of Hematology, AOU Careggi General and Academic Hospital, Florence, Italy, Tel: 055 794 5296; E-mail: